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FDA clears trial of dual-targeted CAR T-cell therapy for cancer

2+ day, 9+ hour ago   (778+ words) The U.S. Food and Drug Administration this week granted permission for investigators at the University of Colorado Anschutz to conduct a clinical trial testing genetically engineered immune cells in adults with advanced colorectal cancer and pediatric patients with solid cancers who…...

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Prediabetes linked to substantial burden of mental health conditions

3+ day, 8+ hour ago   (433+ words) News-Medical Prediabetes linked to substantial burden of mental health conditions Announcing a new article publication for BIO Integration. Prediabetes has a high prevalence worldwide; however, the prevalence of mental health conditions within the population with prediabetes is not well understood....

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New AI tool predicts breast cancer risk using repeated 3D mammograms

3+ day, 21+ hour ago   (505+ words) An artificial intelligence model that analyzes women's past and recent annual 3D mammograms is more effective at predicting five-year risk of developing breast cancer than a tool that uses only the most recent, single 3D mammogram, as well as an AI model…...

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Evaluating new approaches for rare disease research

3+ day, 23+ hour ago   (513+ words) Illumina spoke with its customer Marcel Nelen, head of the Genome Diagnostics department at the University Medical Center Utrecht (UMC Utrecht), one of eight academic centers supporting rare disease genomics research across the Netherlands. His team was among the first…...

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Generative AI-driven drug Rentosertib enters Phase III trial for idiopathic pulmonary fibrosis

4+ day, 1+ hour ago   (946+ words) Insilico Medicine, a clinical-stage biotechnology company powered by generative AI, today announced that it has dosed the first patient with Rentosertib (known as ISM001-055 / INS018_055) in GENESIS-IPF-3, a Phase III clinical trial (NCT07687459, CTR20262475) at Peking Union Medical College Hospital, while Shanghai Pulmonary Hospital…...

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Spleen imaging features may reveal coronary artery disease risk

4+ day, 6+ hour ago   (596+ words) A new study led by investigators from Mass General Brigham reveals that certain features in the spleen hidden within imaging scans may signal a person's risk of coronary artery disease (CAD), suggesting targets for prevention and treatment. Spleen imaging features…...

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Protein-based MRI agent detects tiny lung cancer metastases

4+ day, 6+ hour ago   (301+ words) "Lung cancer is often diagnosed only after it has spread, when treatment options become more limited," Yang said. "Our technology can detect tiny tumors and hidden metastases without exposing patients to radiation. It also helps reveal how aggressive a cancer…...

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The link between PM2.5 and ADHD held up after researchers tested other explanations

4+ day, 8+ hour ago   (260+ words) Two decades of nationwide data reveal contrasting patterns across birth outcomes, diabetes, and childhood ADHD as researchers probe whether the health effects associated with air pollution persist even as U.S. PM2.5 levels decline. Study: Long-term air pollution exposure and childhood ADHD prevalence....

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Laser-carved microvalves prevent hazardous backflow in medical microcatheters

4+ day, 14+ hour ago   (308+ words) The passive architecture suppresses reverse pressure surges by 73.5% during flow initiation and 82.0% during flow shutdown, regulating fluid entirely through geometry without needing moving flaps, batteries, or electronic sensors. Stopping backflow in artificial micro-conduits has long presented a stubborn physics and…...

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Digital program reduces burnout and anxiety in distressed nurses

4+ day, 18+ hour ago   (410+ words) Burnout, depression, anxiety, and suicide are increasing in the nursing and overall health care workforce, which adversely impacts health care quality and safety. Digital program reduces burnout and anxiety in distressed nurses Burnout, depression, anxiety, and suicide are increasing in…...